Louisiana Missouri is located on the banks of the Mississippi River 70 miles north of St. Louis on Route 79 and about 30 miles south of Hannibal, Missouri. Louisiana’s first settler John Bryson built the first residence in 1817 and 1818 sold some land to Samuel Caldwell and Joel Shaw, this area became the original plat of Louisiana which was mainly river-front property. Louisiana boasts nearly 4,000 residents, many whom are descendants of the early settlers.

Louisiana's streets are lined with numerous beautiful antebellum homes revealing their architectural charm of years past, many which are listed on the National Historical Register of Historic Places. The State Department of Natural Resources has noted that Louisiana Missouri has "the most intact Victorian Streetscape in the state of Missouri". Downtown Louisiana commonly known as the Georgia Street Historical District is listed as well on the National Historical Register of Historic Places.

Louisiana is one of three communities forming the 50 Miles of Art corridor, linked by history, heritage & Route 79; Louisiana, Clarksville and Hannibal are home to many fine artists, crafts-persons and artisans where they use their skills to create one-of-a-kind masterpieces. Traveling Route 79 from Clarksville through Louisiana to Hannibal one may enjoy the breathtaking views of the Mississippi River, soaring rock cliffs, rolling hills and colorful landscape.

Louisiana with its historical charm, riverfront beauty & Midwestern charisma, you’ll wish you came to visit sooner.